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Pragmatic trials are studies designed to inform the practice of clinical trials in real life. They are often described by their focus on practical aspects of design that include the recruitment process and consent, adhering and the use routinely available equipment.
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Pragmatic is a software company provides a variety of casino games to online gambling platforms. Its iGaming software is used by the top operators and land based casinos. The company offers front-end website design tools, analysis and promotions, marketing, security payment systems, customer service, and bug reporting. Additionally, the company provides its users a safe environment with high-quality graphics and gameplay.
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A pragmatic trial that uses various investigators and participants from different geographical areas is the Home Blood Pressure Management study (HBPM). This type of heterogeneity is essential for pragmatic trials to be valid, and it also reduces bias in the results. A high degree of heterogeneity, however could cause issues with the design of the trial.
Pragmatic Play is a major player on the live casino market, provides an array of traditional table games such as Blackjack and Roulette. The live studios of Pragmatic Play's offices in Romania and Malta provide customers with an authentic gaming experience as well as a broad selection of virtual betting options. The company also has created numerous interactive game shows that make gambling online enjoyable. Some of these shows feature live hosts, whereas others are hosted by famous personalities from the industry.
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Pragmatic Play is a new player in the world of online casinos however, it has earned a name by offering mobile-friendly slots. Their games are optimised for mobile devices and are powered by HTML5 technology. They are also certified by trusted gaming authorities to ensure transparency and fairness. This is a positive indication for players as it means that the games are checked and verified to ensure that the outcomes of each round are fair and impartial.
Pragmatic Play offers not only mobile-friendly slot machines as well as live casino and table games. Pragmatic Play is licensed by various regulatory bodies such as Malta Gaming Authority and UK Gambling Commission. The company's games are secured with high-end encryption and its security team is available to assist players with any issues.
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Legality
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The goal of pragmatic trials is to replicate real-life scenarios and to achieve maximum validity externally. They are usually commissioned by policymakers and practitioners in order to guide their decisions. They can also be used to determine the causal relationship between an intervention with its outcomes. However, they shouldn't be used in lieu for explanation trials.
The pragmatism concept is controversial and there are concerns about whether pragmatic trials should be used to replace explanatory trials or complement them. Schwartz and Lellouch1 suggested the distinction between explanation studies, which support the validity of a physiological or clinical hypothesis, and pragmatic trials, which inform policy and practice decision-making. They also proposed a framework for pragmatic trials, which they called PRECIS.2 This tool attempted to define the features of a pragmatic study that include recruitment, design and delivery of the intervention, as well as follow-up.
The number of pragmatic trials is increasing. A recent Medline query that used the words pragmatic and naturalistic, limited to randomised controlled trials (RCTs), returned 34 articles. These are highlighted in red on Figure 2. This is an indication that the health sciences community is becoming more sensitive to the issue of pragmatism. It is important to keep in mind that the majority were conducted in primary care settings.