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Pragmatic trials are trials designed to provide information for real-world clinical practice. They are often described as focusing on practical aspects of study design that include the recruitment process and consent, adhering and the use routinely available equipment.
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Pragmatic, a software company provides a variety of casino games to online gambling platforms. Pragmatic's iGaming software is used by leading operators as well as land-based casinos. The company offers front-end tools for design, analysis, marketing, promotions, payment systems, security, customer service and bug reporting. Additionally, the company provides its players a secure environment with high-quality graphics and games.
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Another example of a practical trial is the Home Blood Pressure Management (HBPM) study, which used a variety of investigators and included participants from different geographical regions. This type of heterogeneity which is vital for a pragmatic trial to be valid and lessen the chance of bias, is also necessary. A high degree of heterogeneity, however, can cause problems with the design of the trial.
Pragmatic Play Pragmatic Play, one of the major players in the live casino market, offers a variety of classic table games such as Blackjack and Roulette. The live studios of Pragmatic Play in Romania and Malta offer customers an authentic experience in gambling as well a full range of virtual betting options. The company also has created numerous interactive game shows that make gambling online enjoyable. Some of these shows are hosted live and some include famous people from the field.
Mobile compatibility
Pragmatic Play is a new player in the online casino industry however, it has already earned a name with its mobile-friendly slots. Their games are optimised for mobile devices and are powered by HTML5 technology. They're also endorsed by trusted gaming authorities to ensure fairness and transparency. This is a great sign for players as it indicates that the games have been tested and verified in order to guarantee the randomness and impartiality of each round.
In addition to their mobile-friendly slots, Pragmatic Play also offers table games and live dealer casinos. The company is licensed by a variety of regulatory bodies, including Malta Gaming Authority and UK Gambling Commission. The games are supported by the latest encryption technology, and the company's security team is always available to assist players resolve any issues they might have.
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Pragmatic Play offers a large number of games to play for free before deciding whether you want to purchase them. These games are free and can be played on any device including laptops, desktops, and mobile phones. You can play them anywhere you have an internet connection. They are easy-to-navigate. Some Pragmatic Play websites even let you test your luck while on the move with a practice mod. This can help you get familiar with the game's rules and features before playing for real money.
Legality
Pragmatic Play is renowned for its top-notch games, and for offering an exceptional user experience. Its software can be used on mobile devices as well as in various languages. Despite its infancy, it has already established itself as a top gaming platform for casinos. Its latest releases include Wolves, a 5-reel video slot with a healthy RTP and impressive graphics. Other notable games include Wolf Gold and Chilli Heat.
The aim of pragmatic trials is to simulate real-life scenarios and to achieve the highest level of validity externally. They are usually commissioned by practitioners and policy makers to inform their decision making. They can also be a great way to identify the cause-effect relationship between an intervention and its results. However, they should not, be used to replace explanatory studies.
The concept of pragmatism is controversial and there are doubts about whether pragmatic trials should replace explanatory trials or complement them. Schwartz and Lellouch1 suggested the distinction between explanation trials, which validate the clinical or physiological hypothesis and pragmatic trials that inform the practice and policy decisions. They also suggested the framework for pragmatic trials, which they called PRECIS.2 This tool attempted to define the characteristics of a pragmatic study which includes recruitment, design and delivery of the intervention, as well as follow-up.
There is a positive increase in the number pragmatic trials that are published. A recent Medline search using the keywords naturalistic and pragmatic, which was limited to randomized controlled trials (RCTs) resulted in 34 articles, which are shown in red in Figure 2. This is an indication that the health science community is becoming more sensitive to the issue of pragmatism. It is important to keep in mind, however, that the majority of these studies were conducted in primary-care settings.